home / Forums / Anabolic Zone / HGH, Peptides and SARMS / GH IGF1 ands should I combine them ?
This topic contains 3 replies, has 3 voices, and was last updated by Sciroxx 2 years, 6 months ago.
I’ve been asked more then several times if IGF1 should be combined with GH, and why not to take it by itself or instead of GH usage ?
In a nutshell the ideal solution is using GH in combination with IGF1-lr3 and/or IGF1-DES
It’s true that the IGF1 is the mediator for most of the anabolic effect of the GH, but we must consider 2 things –
The GH has some direct metabolic effect by itself, both in releasing glucose and fatty acid into the circulation, and by this raising metabolism and releasing available energy for anabolic demands, The GH has also a direct effect on nitrogen balance not through the IGF1 path
The IGF1 itself has a direct suppressing effect on the endogenous GH release – so if u inject exogenous IGF you actually and directly suppress any GH present in the circulation
Further more – many GH users are not aware to the fact that GH decreases insulin sensitivity. IGF1 increases insulin sensitivity, and negates this effect, which leads to optimal metabolic conditions. Some users use insulin in conjunction with GH but using IGF1 is much more effective in retaining optimum insulin sensitivity and much much safer
So the ideal solution is combining them both and by this keep optimal serum GH and IGF1 levels
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I’m actually going to be running them together pretty soon. I’ve used them both before but never together so I’m curious of timing. I usually do hgh in the am and then preworkout but also always done igf preworkout. I know some prefer igf post workout so I’m guessing I’ll try that.
Good info, Mr. Sciroxx. Thanks a lot.
Hereinafter are a couple of other scientific based data to support the unique synergistic effect of GH and IGF1
GH and IGF-I combined further enhanced fat oxidation while reducing protein catabolism. Serum insulin concentrations were significantly increased by GH but decreased by IGF-I. GH significantly decreased serum total triiodothyronine concentrations and IGF-I significantly decreased serum corticosterone concentrations.
———–results and conclusions
Administration of IGF-I, but not GH, attenuates dexamethasone-induced protein catabolism and increases insulin sensitivity. Simultaneous treatment with GH and IGF-I additively increases the serum concentration of IGF-I, whole-body anabolism, and lipid oxidation. GH or IGF-I when given alone produces similar increases in the serum concentration of IGF-I. However, GH selectively increases skeletal muscle mass whereas IGF-I selectively attenuates the intestinal atrophy and abnormal intestinal ion transport induced by TPN. These tissue-selective anabolic effects of GH and IGF-I are associated with differential increases in protein synthesis in skeletal muscle and jejunum, respectively.
Simultaneous treatment with GH and IGF-I may offer the greatest clinical efficacy because of improved nitrogen retention in association with enhanced lipid oxidation and stimulation of protein synthesis in multiple tissue types.
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