Scopoletin and epicatechin

theguerrillachemist

I came across this study and thought it was interesting and everyone is always looking to increase performance and increase fat burning! Morinda elliptica(ME) and Morinda citrifolia(MC) leaf extract contain scopoletin and epicatechin, which have multiple metabolic targets in the body. They are critical in increasing ATP production via glucose metabolism and reducing blood lactate and urea levels. In this study, mice were given either MC, ME or green tea extract to see how it affects physical performance. One mechanism is increasing glycogen storage or delaying glycogen breakdown, or both. This would decrease fatigue and allow the mice to swim 5 times longer. Removing ammonia produced during exercise can alleviate mental fatigue by reducing GABA production(like large doses of ornithine in @chemixlifestyle ATP). The study also shows MC and ME can increase PCG-1alpha, the enzyme that regulates mitochondrial biogenesis, as well as increasing UPC1&2(uncoupling proteins that burn fat for energy). Lactic acidosis levels were also decreased which increased performance(similar to how carnosine works as a buffer). Lastly, MC extract significantly upregulated the enzyme that removes ROS(reactive oxygen species) which can cause oxidative stress which leads to fatigue. This study is in mice but the results are very promising. Fun fact: Epicatechin is one of the compounds I used when I formulated the ingredient Endo-Pump(in King of Pumps) for is vasodilation properties which can increase performance via getting carbs/aminos/nutrients into your muscles