(Myo-ITTP) Interesting

Myo-inositol trispyrophosphate(Myo-ITTP) is an interesting compound that may have dramatic effects on exercise performance. One of the major determinants of maximal exercise capacity is delivering oxygen to your muscles. It’s been well documented that having more RBC that cab delivery oxygen can increase performer. Myo-ITTP is a molecule that binds to the membrane of hemoglobin, which promotes the delivery of oxygen to muscle tissue be used during exericse. This study is in healthy mice showed a dose-dependent increase in oxygen saturation in hemoglobin, as well as exercise capacity by up to 57%(distance ran on a treadmill vs the placebo).The researchers then used transgenic mice with severe heart failure(induced by over expression of a gene called G alpha q). Myo-ITTP increased exercise capacity in these mice by up to 63%. This was by injection, but using oral administration the results were still very impressive(increase of 34% exercise capacity). The human equivalent dose is 0.16mg/kg, but anecdotally some athletes have been using around 500mg 3x a week. The half life of Myo-ITTP is around 4-5 days, so it has a build up effect if you are taking it multiple times a week. I believe this is a common practice in horse racing and definitely shows promise for increasing time to exhaustion and endurance in the gym(similar to EPO). More research is needed but it shows promise.