Why are Stubborn fat cells.. Stubborn?

Why are Stubborn fat cells.. Stubborn?⭕️⁣⁣
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Have you ever wondered why some spots are way ‘harder to shred’? I’m talking about lower belly fat, love handles, thighs… yeah all of them.⁣⁣
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Sure, eventually if we diet, all fat is “lost” and there’s no denying that, but.. why is it so hard for some specific areas ? “Upper abs” look shredded, yet the lower ones are nowhere to be found ?! Well, there are reasons for it. Let’s see the first one!⁣⁣
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In laymen terms, when we exercise and diet, our body releases hormones that are responsible for the mobilization of fatty acids, namely Catecholamines (Adrenaline and Noradrenaline). ⁣⁣
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Different areas of body fat have different distributions of alpha-2 and beta-2 adrenoreceptors and this profoundly affects how well or poorly fat can be mobilized and transported out of them.⁣⁣
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Generally speaking, Beta-2 receptors are the “good ones” meaning that they allow fatty acids to be mobilized out of the cells, while Alpha-2 receptors are ghe “bad guys”. ⁣
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As you may have guessed already, subcutaneous areas (exactly those that you probably hate the most) are richer in cells with a higher ratio of Alpha-2 to Beta-2 receptors (even up to 9 times more for thighs), reason why stubborn fat cells are more ‘stubborn’ at releasing body fat. ⁣⁣⁣
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References: ⁣⁣⁣
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https://bodyrecomposition.com/fat-loss/why-is-stubborn-fat-stubborn⁣
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https://pubmed.ncbi.nlm.nih.gov/1309480/⁣
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https://pubmed.ncbi.nlm.nih.gov/3034620/⁣
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3355892/⁣⁣
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https://pubmed.ncbi.nlm.nih.gov/1334970/