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HOW DOES EXERCISE BUILD MUSCLE, EXACTLY?

Discussion in 'Training' started by Zillagreybeard, Jun 11, 2022.
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Zillagreybeard
Zillagreybeard
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  • Jun 11, 2022
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HOW DOES EXERCISE BUILD MUSCLE, EXACTLY?⭕️⁣

I mean, we know that eventually, if we train with weights we end up gaining some muscle mass.. but how, exactly?

Well, when muscle fibers experience tension under load, and a critical threshold is reached, they’re able to signal a cascade of events that convert a mechanical stimuli into a chemical one. ⁣Eventually, these signals lead to hypertrophy.

This process of signaling is called “Mechanotransduction” and, as the name says, it involves the conversion of mechanical stimuli sensed by mechanosensors, and translate them into molecular signaling events that increase muscle protein synthesis rates, and causing the accumulation of protein inside individual muscle fibers as a result. ⁣

In fact, when the mechanical stimulus is sensed by the mechanosensors (supposedly, primarely from Titin) this stimulus is then converted into a molecular signaling event that activated the mTORC1 pathway, responsible for the transcription and translation of proteins via phosphorilation (addition of a phosphate group to the molecule) of the enzyme p70s6k, which elevates Muscle Protein Synthesis, causing the addition of muscle proteins into the muscles!

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